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Conclusion: The neurometabolic alterations observed in the insular cortex of Crohns disease patients suggest increased insular activity, which may enhance interoceptive awareness and pain sensitivity, potentially contributing to heightened pain catastrophizing

There may be increased entry of ammonia into the central nervous system due to increased permeability of the bloodbrain barrier and conversion of positively charged ammonium ion to ammonia, which more readily crosses the bloodbrain barrier, secondary to changes in blood pH

LF has a multilevel effect on iron metabolismdisrupting its homeostasis in cancer cells, leading to their dysfunction, while at the same time restoring the balance of this element in the body

doi:10.1016/j.arr.2024.102634 Bortz J, Obeid R

Other factors that may have influenced these outcomes were species and strain differences, differences in self-administration protocol, and differential impact of blocking D 1 receptors on different neuronal targets at different drug doses