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For these reasons, SKM is a very attractive target for the development of novel classes of antidiabetic drugs

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In another phase 1 clinical trial, 26 pancreatic cancer patients who received gemcitabine monotherapy, gemcitabine combined with cisplatin or gemcitabine combined with carboplatin were randomly assigned to receive eltrombopag 100 mg or placebo every day for 5 days before and after chemotherapy at a ratio of 3:1

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Annu Rev Biochem 2007