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Free Radic Biol Med 86: 200208

Tumor suppressor miR-424-5p abrogates ferroptosis in ovarian cancer through targeting ACSL4

de la Torre BG, Albericio F (2023) The pharmaceutical industry in 2022: an analysis of FDA drug approvals from the perspective of molecules

[DOI] [PubMed] [Google Scholar] 43.Pal S, Bansil P, Bancone G, et al

In mouse models, the team introduced combined therapy including PD-L1 blocker and cyst(e) inase (a bioengineered enzyme that degrades cystine and cysteine) and such treatment can enhance the efficacy of CTL-mediated anticancer effects, supporting the idea that inducing ferroptosis could be considered a productive way for treating cancer and overcoming immunotherapy resistance (Wang et al., 2019)

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