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Nrf2 binds to antioxidant response elements (AREs) to enhance the expression of proteins essential for maintaining cellular redox balance [240, 241]

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A Phase 1b Study of Birinapant in Combination with 5-Azacitadine in Patients with Myelodysplastic Syndrome who are Nave, Refractory or Have Relapsed to 5-Azacitadine