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Effects of high doses: a large excess of vitamin C can cause diarrhea and some other digestive problems, although no toxicity has been evidenced [11]

Taken together, these results suggest that although CRP itself might induce inflammatory cytokines, other molecules modulated by CRP overexpression in HepG2 cells may accelerate the release of inflammatory cytokines from RAW264.7 cells

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The consequence is the crosslinking of protein segments, resulting in altered conformation and protein function

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