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Since copper ions are primarily stored in mitochondria, any imbalance in intracellular copper metabolism can exert cytotoxic effects and lead to pathological processes

Hassler et al., 2014

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Drugs such as sildenafil can inhibit PDE, resulting in a potentially dangerous intensification of the vaso-relaxant effect of nitrates

That being said, cancer stem cells survive these treatments due to their lower translational needs and eventually mutate the proteasome proteins to acquire drug resistance that leads to the cancer relapse (Oerlemans et al

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