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EGFR also induces ERK2 to phosphorylate PKM2 at Ser 37, which allows peptidylprolyl cis/trans isomerase NIMA-interacting 1 (PIN1) to bind to PKM2, prompting PKM2 to translocate to the nucleus, upregulating lactate dehydrogenase A (LDHA) and glucose transporter 1 (GLUT1) expression and promoting the Warburg effect (Yang et al., 2012b)

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Further support of this mechanism was indicated in one of the clinical trials with early postmenopausal women in which those taking Maca-GO experienced statistically significant changes in other pituitary-regulated hormones, including cortisol, adrenocorticotropic hormone (ACTH), and triiodothyronine (T3), compared to placebo [26]

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Recently, neural activity mediated by NMDA-receptors (NMDAR) has been coupled with transcriptional activation of glutamate-cysteine ligase, a key enzyme in GSH production, leading to a sustained GSH-based protection against an oxidative insult 26