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Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

doi: 10.1172/JCI40053

The analyses of 5 -reductases in humans and animals highlight the differences between testosterone and DHT, and the significance of DHT in male sexual differentiation and prostate physiology and pathophysiology

cytoplasm), isocitrate dehydrogenase-2 (IDH2

The study was conducted in accordance with the Declaration of Helsinki and with the approval of the City of Hope Internal Review Board (IRB #13447)

Acknowledgments We would like to acknowledge the Crystal Charity Ball and the NeuroNICU program at the University of Texas Southwestern Medical Center for supporting this project