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Both tumor and stromal cells release exosomes that carry specific addresses and are selectively internalized by recipient cells to modulate the TME locally or travel through the circulation to other organs [138]

Since the clinical steady-state C max concentration is higher than their IC50, these TKI agents can make patients with a high incidence of hyperbilirubinemia by effectively inhibiting UGT1A1 (218, 219)

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