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Its inclusion in the Category 2 restricted list has drawn criticism from clinicians who point to its legitimate international approval record as evidence that the safety concerns cited by the FDA are inconsistent with the global clinical literature

Although there is no direct evidence of a causal role of CD38 in neurodegenerative diseases, as discussed above, CD38 is emerging as a key enzyme involved in inflammageing and senescence 45,105,106 , which are strongly associated with neurodegenerative diseases 124,128,168,169

Together, they enhance tissue regeneration, inhibit inflammatory signaling pathways, and modulate pain transmission, offering a comprehensive approach to alleviate inflammation and pain

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10.1016/s0166-2236(98)01299-5 14 DjakovicZ.DjakovicI.CesarecV.MadzaracG.BecejacT.ZukanovicG.et al (2016)