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To search for regions of homology to the mtDNA within the reference nucDNA, we used BLASTn 2.13.0 with the GRCh37 reference genome with a word size of 11, an expected threshold of 0.05, short queries enabled and default values for the other parameters

Coenzyme Q10 (CoQ10) is a fat-soluble, vitamin-like compound that is absolutely essential for the production of ATP

For instance, polymorphisms in GPx4 or SOD genes, micronutrient deficiencies, or impaired recycling of antioxidant pools can predispose individuals to a redox imbalance without overt clinical markers (67)

Mechanistic insight from broader reviews of antioxidant systems Lu, Y., et al

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Whether cagrilintide or CagriSema preserves more lean mass than GLP-1 receptor agonists alone remains an open question that future studies need to address