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however, further subgroup analysis based on sex did not identify significant prognostic effects in female patients, indicating that the insignificant prognostic effect in females was overshadowed by that of males when evaluating males and females as a whole

Annals of internal medicine

doi: 10.1016/j.oooo.2012.12.012

"Methanocaldococcus jannaschii uses a modified mevalonate pathway for biosynthesis of isopentenyl diphosphate"

The tolerable upper intake level (UL) for adults is 3,500 mg/day
