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In total, 53 positive and negative regulators of PARKIN expression were identified, and among them, the functional validation of the transcriptional repressor, THAP11, demonstrated that the regulation of endogenous PARKIN directly modulates phospho-ubiquitin accumulation in multiple cell types, including NGN2 -induced hPS cell-derived DA neurons, thereby linking PARKIN expression level to mitochondrial damage signaling and highlighting targets to restore mitophagy capacity 30

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Intense research has been undertaken to determine the critical elements of such responses and putative therapies for their suppression

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doi: 10.1093/ijnp/pyu070 163 GrateIGarca-BuenoBMadrigalJLCasoJRAlouLGmez-LusMLet al

Point-of-care genetic screening allows identification of high-risk patients before the first dose, though debate continues over universal versus targeted implementation