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2015, 5(2) 545-589 Biological aspects of reactive nitrogen species

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Recent studies have identified following a regimen of moderate and prolonged treadmill training (30 m/min, 45 min/day, 5 days/week, 8 weeks) in rats of 48 h post MI, the SIRT1-p53 and SIRT3-FoxO3a-dependent signaling pathways are activated within the infarcted myocardium to reduce cardiomyocytes apoptosis and oxidative damage, showing exercise training to mitigate the early harmful effects of MI [53]

F.H., B.F., R.D

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