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How Much Vitamin B12 Is too Much

We aim to support, not substitute, the doctor-patient relationship

J.KlepzigK

Mutant IDH1/2 produce D -2HG at levels more than 100-fold higher than normal in tumor tissue studies ( D -2HG, whereas L -2HG arises via different enzymatic defects ( Scheme 1 2.1.2 Hydroxyacid-oxoacid transhydrogenase The enhancement of oncometabolite concentration can occur through multiple mechanisms, not limited to IDH mutations

Laron Z: Laron-type dwarfism (hereditary somatomedin deficiency): a review
J Am Chem Soc 142(11):51775183
