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In experiments involving HO-treated human skin fibroblasts, treatment with sea buckthorn PCs significantly decreased ROS levels and notably restored the morphology of senescent cells while enhancing cellular activity

[DOI] [PubMed] [Google Scholar] Fukuda M

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In recent years, plantderived bioactive compounds have gained attention as potential alternatives or adjunct therapies to levodopa due to their neuroprotective, antioxidant, and antiinflammatory properties [14, 15]

It is newly reported that iron is correlated with parkinsonism symptoms in a PD mouse model with mutation in Pla2g6 gene (phospholipase A2 group VI), and that iron-catalyzed lipid oxidation modification reduces glutathione peroxidase 4 activity and content 8 , which is related closely to PD