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On the other hand, systemic studies, which aim to examine broader impacts across the body, require higher doses to ensure adequate distribution

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10.3390/biom9010034 110 PrzyborowskiK.WojewodaM.SitekB.ZakrzewskaA.KijA.WandzelK.et al (2015)

Given the extreme reliance of this specialized type of neuron on mitochondrial oxidative phosphorylation for ATP production, it is not surprising that secondary mitochondrial dysfunction is a central and consistent hallmark of both idiopathic and familial forms of PD [135]

Rights and permissions About this article Cite this article Dunbar, E.M., Coats, B.S., Shroads, A.L

Chronic treatment with HP is known to induce oxidative stress due to the increased turnover of dopamine (17)