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doi: 10.1007/s10815-013-0047-5 120 StanislavovRNikolovaVRohdewaldP
[DOI] [PubMed] [Google Scholar] 320.Mai X.-M., Langhammer A., Camargo C.A., Chen Y

Schmidt T.G.M., Batz L., Bonet L., Carl U., Holzapfel G., Kiem K., Matulewicz K., Niermeier D., Schuchardt I

19,20 With aging, mitochondrial function declines, leading to decreased energy metabolism, increased ROS production, and the accumulation of mtDNA mutations, alongside the deterioration of other mitochondrial functions

You get an initial glow in 2 to 3 weeks, but for the whitening effect, you may have to wait as it develops gradually over time