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10.1016/j.immuni.2021.04.021

Haku et al., 2018)
MMPs (such as MMP-1, -2, -3, -7, -9, -13, 14, and ADAMTS-4) are upregulated in IDD and correlate with the severity of degeneration (Huang YC
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CGRP and the nerve-bone connection Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide that has fundamentally changed how researchers understand the relationship between the nervous system and bone health