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Kopetz S , Grothey A, Ciardiello F, Desai J, Kim TW, Maughan T, Cutsem EV, Wasan HS, Yaeger R, Yoshino T, Gollerkeri A, Edwards M, Lizaso MR, Tabernero J

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Specifically, activation of NF-B and AP-1 signaling pathways induces key pro-inflammatory cytokines including TNF- and IL-1, thereby modulating inflammation and immune responses [101, 102]

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This pathway has been studied in several in vitro models and is under investigation as a potential therapeutic target in several cancers, including breast, ovarian, liver, and prostate 15,16,17,23

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