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Another recurring limitation emerges on antioxidant-based interventions in ASD, constrained by a fundamental methodological gap: most clinical studies report behavioral or functional improvements without directly measuring oxidative-stress biomarkers

LASSO analysis penalizes proteins with only minor contributions in determining metabolite abundance by assigning a coefficient of zero, which nominates proteins that can be prioritized for biological validation

We found that age, BMI, pre-ODI, pre-JOA, and JOA improvement rates were in line with a normal distribution

The possible mechanism of action (MOA) of ZNT in the SMG environment, as per our hypothesis, is elucidated in Fig

Arabidopsis has three HPR isoforms: peroxisome-localized NADH-dependent AtHPR1, cytosolic NADPH-dependent AtHPR2, and chloroplast-localized NADPH-dependent AtHPR3 (Timm et al., 2011)