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& Rhoderick, J

Jaimez-Ordaz, J., Martnez-Ramos, T., Gonzlez-Cruz, L., & Aparicio, A

10.1111/j.1476-5381.2010.01166.x 27

On the ROS source side, NOX isoform modulation (isoform-selective inhibitors or genetic silencing) dampens pathological microdomain fluxes while preserving host defense and organelle-targeted approaches (e.g., reinforcing mitochondrial quality controlbiogenesis/mitophagy, precise control of Ca handling and RETrather than blanket scavenging) recalibrate matrix and IMS redox (Altenhfer et al

The alterations observed in lipid metabolism in patients with GWS and ME/CFS suggest potential mitochondrial dysfunction, which may underlie the profound fatigue characteristic of these conditions (Germain et al., 2018, 2020, 2022