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E.et al (2024)

Amphetamine and other psychostimulants reduce pH gradients in midbrain dopaminergic neurons and chromaffin granules: a mechanism of action

Cell 185:881-895 e820 Sumbalova Z, Kucharska J, Rausova Z, Palacka P, Kovalcikova E, Takacsova T, Mojto V, Navas P, Lopez-Lluch G, Gvozdjakova A (2022) Reduced platelet mitochondrial respiration and oxidative phosphorylation in patients with post Covid-19 syndrome are regenerated after SPA rehabilitation and targeted ubiquinol therapy

Therefore, plasma TMAO levels are influenced by multiple complex factors, especially the amount of TMA precursors and dietary TMAO sources in the diet, the dominant genera in the gut microbiota, FMO3 enzyme activity, and kidney functions