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Similarly, the AMPK Blend provides additional upstream AMPK activation through plant-derived compounds that complement MOTS-c's intracellular mechanism

doi: 10.1016/j.ejphar.2020.173761 151

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Nrf2-dependent upregulation of HO-1 in curcumin-treated renal tubular epithelial cells challenged with high glucose concentrations was shown to prevent phenotype changes resembling fibrosis and known to occur at an early stage of diabetic renal injury (23)