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Orlowski and Meister found that the ATP-driven reaction that combines glutamate and cysteine to generate -glutamyl cysteine (catalyzed by -glutamyl cysteine synthetase) (Figure 4A) can actually be subdivided into two distinct reaction steps (Figure 4B) (38,54)

For instance, iron chelators such as deferoxamine and deferasirox effectively reduce iron overload and improve iron-related damage

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Glutathione cycling between the symplast and apoplast may represent a way to transfer redox information

Ankarcrona et al., 2009
