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Large IV or oral doses of ascorbic acid have caused hemolytic anemia in some patients with G6PD deficiency (glucose-6-phosphate dehydrogenase deficiency)

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Interestingly, MET promoter variant rs1858830 signaling appears to contribute to gastro-intestinal abnormalities associated with ASD (Rudie et al., 2012

For those who have trouble absorbing Vitamin B12 from diet or supplements, long-term injections may be required

Y.KikuchiC.ZajaI.et al (2013)