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LC-MS/MS analysis was performed on an Acquity UPLC H-Class system (Waters) equipped with an Acquity UPLC BEH C18 1.7 m (2.1 50 mm) column (Waters) and an MS detector (Xevo TQD, Waters)

10.1038/s41564-019-0498-2

Furthermore, cadmium exerts long-term toxicity through epigenetic silencing, even recent studies indicate that it induces hypermethylation of the metallothionein 1A (MT1A) gene promoter (57)

J Immunol 172:442448

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