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mRNA sequencing and analysis Total RNA of kidneys from three rats was extracted with TRIzol (Invitrogen, #15596026)

Quercetin derivatives with good solubility, high bioavailability, and significant biological activity were obtained through optimized modification (172)

For a common working concentration of 2.5 mg/mL, add 2 mL of solvent directly to the lyophilized vial and allow it to dissolve gently without vortexing, as aggressive agitation can cause peptide aggregation and loss of bioactivity

These studies showed that the total SOD activity was decreased and SOD down-regulation in cartilage may be involved in the development of OA

Its prevalence is increasing at an alarming rate, and the affected population is becoming increasingly younger, posing a serious threat to both individual health and social well-being