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The evidence combined BPC 157 with the time-dependently activated VEGFR2-Akt-eNOS signaling pathway, the increase in endothelial tube formation (chick chorioallantoic membrane (CAM)) (both suppressed by Dynasore, an endocytosis inhibitor), the increased expression and internalization of VEGFR2, and essential acceleration of blood flow recovery and vessel number to rescue hind limb ischemia in rats with a completely excised femoral artery [94]

Treatment of superficial venous incompetence can be accomplished by different techniques including gradient elastic compression stockings, ligation and stripping, sclerotherapy, ultrasound-guided sclerotherapy, endovenous laser or radiofrequency thermal ablation, cutaneous lasers, and intense pulse light devices [15, 16]

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Moreover, vitamin C injections can aid in wound healing