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Adipocyte lipolysis published in vitro studies have characterised AOD-9604's stimulation of lipolysis in isolated rat and human adipocytes

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The peptide proceeded through Phase IIb clinical trials for obesity, where it demonstrated favourable safety but failed to meet weight-loss endpoints at the doses tested

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Results in the study demonstrate that IGF-1 induces the opposite effects since the IGF-1 deficit reduces the expression of glucose-6-phosphatase and phosphoenolpyruvate carboxylase-1