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In general, folate regulates hepatic lipid metabolism through a variety of mechanisms, playing a role in delaying liver metabolism, inhibiting fatty acid synthesis, promoting fat oxidation, and reducing oxidative stress and inflammation

While retaining their binding to cartilage, these fragments were able to carry payloads such as an MMP-cleavable form of viral IL-10 60 and soluble TNF receptor II, 33 enabling the in vivo imaging of murine OA cartilage

These were assessed with an HRP-conjugated polymer system (K5007, Dako, Germany) and a Leica DM2000 scanner (Leica Biosystems, Wetzlar, Germany)

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