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10.1016/j.jtcme.2016.12.013 62 MudriJ.ekiL.KrgoviN.Medarevi.avikinK.RadanM.et al (2025)

Reduced ability of HDL to stimulate NO production from endothelial cells and decreased vasorelaxation properties are reported for T2DM (887,888), T1DM (889), mild chronic kidney disease (CKD) (890), and rare forms of autoimmunity (ALPS) (891)

This is evident in IBDs such as Crohns whereby patients have been reported to express receptor variants to IL-23, a cytokine primarily expressed by macrophages and found in elevated abundance in the intestinal mucosa of Crohns patients (Duerr et al
2023 Feb;30(1):3148
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GAPS diet frequently includes high-density, easily digestible foods with high nutritional values
