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The LR3 modification significantly lowers its affinity for these binding proteins, meaning more of it remains unbound and biologically active

[9] This process is extremely slow, with the half life at 25 C of between 350 and 600 years per bond

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Combining these findings with clinical experience and data from case series which suggested possible efficacy re-treatment with immunoglobulin in GBS led to consideration of the possibility that some individuals may have a quicker IgG clearance and hence require higher dose or repeat treatment, to achieve a potentially improved outcome

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The cellular and organismal effects of nitroxides and nitroxide-containing nanoparticles