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But, for researchers and clinicians alike, a nuanced understanding of their limitations, accompanying obstacles, and effectiveness is essential

For B12 to be absorbed, it requires a protein called intrinsic factor (IF), which is secreted by the stomachs parietal cells (3)

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Thus, in normal aging, a decrease in GSH couples with an age-related increase in labile Fe 2+ to multiply the likelihood of ferroptosis, leading to death when combined changes in iron and GSH reach a critical threshold (Figure 7)

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These effects are essential for maintaining energy efficiency under metabolic stress, supporting research into fatigue resistance and cellular longevity