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Prior to entering the nucleus, conjugation of the activated cisplatin with glutathione (GSH) by GSH S -transferases (GSTs) ( C ), or interaction with the sulfhydryl-containing metallothioneins ( D ) can result in reduced drug efficacy

[DOI] [PMC free article] [PubMed] [Google Scholar] 105.Elzoghby A.O., Samy W.M., Elgindy N.A

This variety offers superior dry traction in exchange for limited wet traction and even lesser wear characteristics

[DOI] [PubMed] [Google Scholar] 110.Chiu P.Y., Ko KM

Additionally, by elevating PPP-related enzymes, nucleotides are more accessible, facilitating TC cell proliferation

BET inhibitors In recent years, a substantial number of BET inhibitors have been identified, encompassing pan-inhibitors, BD1/BD2 selective inhibitors, dual inhibitors of kinases and BET, and PROTACs-based inhibitors