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In this context, it is suggested that the tumor microenvironment has an extraordinary effect on the systemic immune system, and reduced inflammatory status after surgery should be a strong impact on the prognosis

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Instead, research points to activity across multiple interconnected systems, including modulation of the nitric oxide (NO) system, upregulation of growth factor expression (notably VEGF, EGF, and FGF pathways), promotion of angiogenesis, and activation of the FAK-paxillin signalling pathway involved in cell migration and tissue organisation

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119,120 These molecules are usually not recognized as DAMPs when the organism is in a steady state