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45 The citrullination of histones by PAD4 is a crucial step in this process, as it alters their charge and structure, facilitating their release from chromatin and promoting the formation and stability of NETs

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If intolerable side effects occur during escalation, remain at current dose for an additional 4 weeks before attempting to increase, or drop back to the previous dose

BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide consisting of 15 amino acids, with a partial sequence derived from body protection compound found in gastric juice

Faria et al., 2019)