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However, RNAi therapeutics still face technical obstacles, such as achieving efficient delivery of RNAi drugs targeting organs or tissues and overcoming the off-target interactions (Persengiev et al., 2004

Many have reported increased energy levels, improved mood, and renewed vitality

Dec 2024;49(4):463-479

Wang et al., 2020)

To avoid and manage these problems, one approach is Robert and Szabos concept of cytoprotection, which holds innate cell (epithelial (Robert) [41,42,43] endothelial (Szabo) [43,44,45,46,47]) integrity and protection/maintenance/reestablishment in the stomach to be translated to other organ therapy (cytoprotection organoprotection) [48,49] via the cytoprotection agents effect

The NOD2 receptor regulates the commensal gut microbiota, through the restriction of the total number of bacteria and limiting the colonization by pathogens, especially in the terminal ileum [31]