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Supplementary Materials Data Availability Statement The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding authors.

Then, 5% of the supernatant was taken from the no-bait control to serve as input

3 Department of Medical Chemistry, Faculty of Medicine, University of Indonesia, Jalan Salemba Raya 6, Jakarta 10430, Indonesia

In the Q175-HD mouse model, upregulation of the GSTO2 protein has been reported at 6 months, when motor deficits are not fully developed 60

The labile iron pool, which consists of redox-active Fe 2+ , requires strict regulation because of its potential to generate harmful ROS through Fenton chemistry (Figure 4)