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The HPG axis is responsible for the production of testosterone, the main sex hormone in males, other sex steroid hormones (dehydroepiandrosteroneDHEA, androstenedione, dihydrotestosterone, estrogen, and progesterone), peptide hormones (activin, inhibin, and follistatin, which are included in feedback mechanisms and spermatogenesis), production of spermatozoa (sperm cells), and sexual arousal (11, 15)

doi: 10.15252/embj.2020107100 Summary Keywords DNA methylation and DNA demethylation, diabetic retinopathy, age-related macular degeneration, glaucoma, schizophrenia, autism spectrum disorder, intellectual disability, Alzheimers disease and Huntingtons disease Citation Xu C, Fu X, Qin H and Yao K (2024) Traversing the epigenetic landscape: DNA methylation from retina to brain in development and disease

In brief, HEK293T cells (American Type Culture Collection (ATCC), CRL-3216) were cultured in complete DMEM (Gibco, 11965-092) supplemented with 10% (v/v) FBS (VWR, 97068-085) and 1% penicillinstreptomycin (VWR, 16777-164) at 37 C under 5% CO 2