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The high OCTN2 expression is associated with poor overall patient survival and a siRNA-mediated OCTN2 silencing in GBM led to a loss of tumor cell viability (Wang et al., 2012)

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In addition, mitochondria also play an important role in influencing intracellular calcium levels, reactive oxygen species (ROS) production, regulating innate immune responses, and apoptosis ( Androgens can regulate glucose and lipid metabolism by affecting mitochondrial density, quality, and function
