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Our data similarly revealed that DSF alone, especially at low concentration, had negligible effect on the activation of cGAS-STING pathway, while a combination treatment of DSF and Cu (II) at extremely low dose significantly and consistently triggered this pathway across multiple cancer cell lines, highlighting the critical role of Cu addition in activating innate immunity

Stovell MG, Helmy A, Thelin EP, Jalloh I, Hutchinson PJ, Carpenter KLH

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59 Altogether, there is significant variability and inconsistency in the literature surrounding the role of iron in macrophage polarization, likely due to variability in initial polarization state, origin of the macrophages, and length of treatments