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Low-dose spironolactone combats dyslipidemia and hepatic inflammation by modulating PCSK9 in rat model of polycystic ovarian syndrome
V.Souza RodriguesQ.Silva SantosG.NavaniR.NavaniA.et al
Therefore, replacing the disulfide bridge with a lactam bridge resolved two key formulation and chemical stability challenges, removing the possibility for oligomerization through disulfide shuffling and allowing for formulation at desired neutral pH
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