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A talk someone posted recently by a doctor mentions that he treats patients with methylfolate and not folic acid

Even for those with mild deficiencies, B12 shots can: Boost metabolism Aid in weight loss Improve sleep Increase energy Lift mood Strengthen immune system Decrease risk of birth defects Decrease risk of cardiovascular disease B12 injections are administered into muscle tissue, providing a quick and effective treatment with numerous health benefits

Most published findings on both compounds are from rodent models

5 Benefits of Hydroxocobalamin: Restoring B12 levels Hydroxocobalamin is effective in treating macrocytic anemia associated with vitamin B12 deficiency, particularly in conditions such as pernicious anemia and malabsorption syndromes

These mental health effects can be minimized with a slow, guided taper overseen by a doctor

Genetic disorders of vitamin B(1)(2) metabolism: eight complementation groups--eight genes
