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Older adults (there is reduced stomach acid production with age, and acid in the stomach is necessary to absorb vitamin B12)

In clinical trials, 100% of healthy volunteers experienced this chromaturia with administration of 5g hydroxocobalamin with other common effects including erythema, rash (predominantly acneiform appearance) and increased blood pressure

However, fast-drying poly is less forgiving than the regular polyurethane
Its key to talk to doctors about managing these interactions and making sure B12 supplements work well

One looked at 16 patients with knee pain