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Somatic mutations are the second mutations that occur and may also be another small mutation or the loss of the remaining allele of the gene

REFERENCES 1.Lenane P, Powell FC

DOI: 10.1021/ic801448w 36

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Rabbits indeed appear to be a better model than mice for the study of atherosclerotic effects of apoC1, because (1) rabbits fed with cholesterol-rich diet spontaneously develop atherosclerotic lesions, as humans but not as mice [143] (2) plasma lipid profile of rabbits is closer to humans than the one of mice and (3) rabbits, like humans, express endogenous, active CETP [144]