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For specialized uses, such as high-dose intravenous vitamin C in clinical settings, even larger amounts are used under medical supervision
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EBioMedicine 76, 103847
These results indicate that CSE treatment did not significantly impact barrier integrity, but led to increased cytotoxicity, elevated inflammatory markers, and heightened oxidative stress
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HI led to a significant increase in the ratio of mitochondrial DNA to nuclear DNA (mtDNA/nDNA), in the ipsilateral side of brain in both male and female rat pups following HI [146]
