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A weaker heart might not be able to pump blood, which results in shortness of breath and edema

Melatonin in chronic pain syndromes

negative tests may help clarify the picture when the result of other testing is unclear

Neurochem Res 42:16611675

Overall, only three studies were deemed of good quality
Role of presynaptic muscarinic and GABA(B) receptors in spinal glutamate release and cholinergic analgesia in rats
