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Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles heel

Han X, Zhang T, Liu H, Mi Y, Gou X

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Still, it influences the release of TGF-1, the activation and proliferation of fibroblasts, and their differentiation into myofibroblasts, mostly mediated by the RANKL/NF-B pathway

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Non-transferrin-bound iron (NTBI) can enter cells via the zinc transporters ZIP8 (SLC39A8) and ZIP14 (SLC39A14) [20,21], while iron bound to the extracellular matrix polysaccharide, hyaluronan, is proposed to bind CD44, with the resulting complex being taken up by endocytosis [22]