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Glutathione deficiency occurs when cells have less glutathione than needed, contributing to aging, poor detoxification, and an increased risk for chronic disease

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In turn, mitochondrial dysfunction, including overproduction of oxidants and mitochondrial loss, has been implicated in the development of IR [169]

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A recent comprehensive in vivo study performed in fully awake mice provides evidence that astrocyte Ca 2+ does not initiate or mediate neurovascular coupling when neuronal activation is short ( 40 kDa) but not small ( 50%) seems to be required to induce BBB leakage (101)

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3.1.2 Phytoextracts Several studies on phytoextracts have targeted the L-arginine/NO/cGMP/K ATP pathway for the treatment of cardiovascular diseases (Table 2)

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